Traditional Chinese medicine has experienced dynamic extraction dynamic extraction, dynamic reflux extraction, dynamic circulation continuous reflux extraction three steps.
Dynamic extraction step
Relative to the immersion method for, decoction method, permeability of backflow method, capsules all belong to dynamic extraction.
Decoction method is the medicine yinpian or thick powder for the decoction, and add water to make submerged medicinal herbs, soaking appropriate 96 second article of Chinese herbal medicine composition between extraction, heated to a boiling, and keep the boiling to certain time state extraction method. Medicine yinpian and thick powder surface of effective ingredients of concentration on the boiling water is poor mixing effect and implementation, general than immersion method to extract the effect is good. If on the mezzanine pot, provision of extractor extraction equipment such as adding a mixer, pumps, etc, which can realize forced circulation, improve extraction efficiency. But because the decoction method used more water for solvent, high temperature, applies only to effective component soluble in water, and a hot, damp herbs of the more stable.
Permeability method also belong to dynamic extraction capsules, medicinal powder in thick is seeping inside the capsules, pharmaceutical raw materials solvent continuously from the permeability of the upper join filter, oil seeping constantly from the lower flow out, thus leaching of medicinal materials of effective ingredients of method. According to the different method of operation, but will permeability of permeability of single capsules capsules, heavy permeability and pressure capsules permeability of capsules, counter-current permeability of capsules method, etc. One single capsules used more solvent method permeability; Heavy permeability of a solvent a capsules can DuoCi use, the solvent consumption is single permeability method to reduce capsules, and permeability in the fluid of effective component capsules of high concentration, don't have to heating enrichment, can avoid the effective component thermal decomposition or volatile loss, product quality is good, but accounts for larger container, the operation of trouble, more time consuming; Seepage pressure capsules can make the solvent and leaching solution quickly through the powder column, make the permeability source smoothly, improve the leaching effect, extract concentration, solvent consumption is small; Glutathione Counter-current permeability source method is medicinal materials and the solvent in leaching tank in the opposite direction along the movement, the continuous and fully contact with the method of extraction, belong to dynamic reflux extraction.
Backflow method is with ethanol, and other volatile organic solvent extraction medicinal materials effective components, will leaching solution heating distillation, including volatile dissolvent again after gasification by condensation, to flow back to the leaching sedimentate polysaccharose, medicinal herbs, sample round and round, until the effective components from the method of completely. Resveratrol Reflux method can be divided into backflow hot leaching and backflow quenching method. Reflux method is better than the permeability of capsules solvent consumption is small, the solvent can recycle, but hot leaching solvent can only backflow recycling, can not keep new and the backflow quenching method can recycle solvent, and can be updated, the solvent consumption, dip is completely carry. Due to continuous reflux method heating, dip carry liquid leaching in the heating time is longer, so does not apply to heat of the damage of medicinal ingredients to leaching.
Dynamic reflux extraction step
Spiral reflux extraction device spiral reflux extraction using dynamic principle, the diffusion of medicinal materials particles interface effective ingredient drug around quickly to solvent diffusion, diffusion interface always maintain higher concentrations inside and outside is poor, and to realize the principle of application reflux extraction work period medicinal materials particles inside and outside maintain a uniform interface spread the concentration of the poor.
Reflux extraction device, cast by hopper, feeding conveyor for spiral, rotary extraction roller, slag discharge spiral conveyor for composition. The material coarse crushing, gradually after extraction from the shots in the hopper, by feeding conveyor for spiral compulsory pushed into a rotary extraction in the drum, slow roller rotation, fixed in the roller on the wall with the spiral materials from the front to back slow progress, and extraction solvent from the end of the unit into liquid pipe into the extraction in the cylinder, the roller back-end through the material move forward end flow, solid-liquid two-phase material in this reverse movement full contact, and the effective components of medicinal materials extracted. The liquid dregs spiral conveyor for mandatory push to the mouth and slag discharge units, Chia seed and the dregs of liquid to spiral and for extrusion, will the residual liquid solution extrusion medicinal material organization, reduce the residual liquid solution content. 97 Chinese herbal medicine composition extraction and separation and preparation processing new technology and new process, new standard practical handbook 98 Chinese herbal medicine composition of the second article extraction technology spiral pole type continuous reflux extraction equipment is dynamic extraction, reflux extraction, decoction extraction technology, combined with the traditional process in reserve DuoZhong advantages at the same time, create the traditional process can achieve many advantages: extraction speed is quick, effective components from fully, extraction yield high; Solvent consumption, high concentration of liquids, reduce evaporation and concentration for treatment working procedure; Roller herbs in movement speed adjustable particles, which can adjust according to the characteristics of herbs extraction time length; Medicinal materials in mild dynamic environment is extracted, and heating temperature is lower, effective component little damage, make solution impurity content in the less; Belong to successive production, processing power.
Dynamic warm immersion extraction equipment dynamic warm immersion extraction equipment is using machine forced circulation method, Docetaxel the solvent extraction in the interior of the top-down continuous loop, the current leaching, make solid, liquid two-phase produce higher relative velocity, and the diffusion boundary layer become more thin, speed up the solute in medicinal materials to the spread of solvent. Dynamic warm immersion process flow chart.
Figure dynamic warm immersion process:-dynamic warm immersion cans, -clip casing heater; -pump; -solvent storage tanks; -the condense pipe; -cooler; -among solvent dynamic warm immersion technology slot, has the following characteristics: leaching temperature is low decoction method, which can prevent medicinal materials, colloid material in starch gelatinization, excessive inflation, influence the solute, can avoid again because of its tremendous leaching and cause separation and enrichment difficulties; Medicinal material surface area, increase the speed of the solute dissolution, spread; Leaching time short, solid, liquid two phase of the relative velocity increasing, and the diffusion interface layer updated quickly, solute diffusion balance time short; Less solute loss. Chinese herbal medicine composition extraction and separation and preparation processing new technology and new process, new standard practical manual MiaoQing methamphetamine content in as the evaluation index, compared the decoction method and dynamic warm immersion extraction extraction effect: a using decoction method, double the amount of water, decoction times, each time, three times with extract, measured in methamphetamine for); Another use dynamic warm immersion technology, double the amount of water, dip mention temperature, extraction twice, first, for the second time, merger extract, measure the content of methamphetamine for). Fructus schisandrae ethanol solvent same dosage, Irinotecan reflow law to extract two times, each time 0, fructus schisandrae b element content measured for); Dynamic warm immersion [(1)] extraction two times, each time, with the method of fructus schisandrae, of content is 11 b). Because forsythia ester unstable nucleoside properties in acid, encounter heat can decompose and RenYanJiu on the dynamic extraction research; In solvent extraction temperature, dosage, extracting time as examine factors, USES the two orthogonal table test, the best dynamic were extraction technology conditions for 0 times the volume of water, 1 continuous dynamic extraction 0. Compared with the traditional decoction method, dynamic extraction (thick powder) method is presented for) a nucleoside ester content 3), and Fried cooking method for) 3). Visible dynamic warm immersion extraction has spread quickly, mass transfer process temperature advantages, can avoid the leaching time is too long and lead to destruction of effective ingredients of decomposition.
Dynamic continuous reflux extraction phase cycle step
Dynamic cycle stages in 0 th century against extraction s began to use. The first is the extraction of circulating dynamic tank, its characteristic is exterior heating, and the cycle solution dynamic extraction, slag discharge mouth have mesh, filter board, can own filtering, has a lot of function, can a single tank extraction, cans group downstream, counter-current extraction. Two-way exterior heating the cycle of dynamic extractor in years began to use, Plant extracts in addition to the cone type and dynamic characteristics extractor as circulation outside, still have the following features: the central a cylindrical tanks in type heater, outside the sandwich divide, the next two section, cellular welding, circulating pump flow, head of the low.
Dynamic circulation continuous reflux extraction phase is for the Chinese medicine routine use of solvent extraction method is insufficient, will DuoGe extraction unit scientific combination, between units concentration gradient (material and solvent) reasonable arrangement and the corresponding process configuration. Each unit use forced circulation by mechanical means method, the solvent top-down or bottom-up continuous cycle, the current leaching, make solid, liquid two-phase produce higher relative velocity, improve the solid 4 liquid interface layer diffusion of updated speed, improve leaching efficiency. Source:www.cospcn.com