Oral lichen planus is a chronic inflammation in oral mucosa. It is a multifactorial disease with the occurrence of 0.5% to 2%. It is the result of the interaction of genetic and lifestyle factors. Most patients had spontaneous pain, anxiety and limiting the mucosa clinical symptoms. It affects the daily lives of patients. Tretinoin has a significant effect in the acute phase oral lichen planus.

After treatment with oral lichen planus returned to retinoic acid: white pattern loss, erosion healing, oral complaints. A major improvement: white-structured part of the loss of redness, congestion, reduce erosion of the surface is almost healed, the pain in the mouth. There was some improvement: surface erosion closely patterned white light, redness, relieve congestion, and sometimes spicy foods always cause more pain.

The lack of pathological manifestations of OLP epithelium and actinic keratosis, hyperkeratosis formation, thickening of the basal layers of the epidermis liquefaction and lymphocyte infiltration of the dermis film. Studies have shown that cell-mediated immune response, cytokines and apoptosis in part the situation of non-keratinocytes in oral lichen planus, the development of the most important factor. Cytokines and keratinocyte cell infiltrates of inflammatory cells, stimulates the inflammatory cell infiltration of the skin into the bloodstream of the country. To verify that the induction of IFN-c expression of adhesion molecules and adhesion functions in oral mucosal immune system, which interacts with the immune response in the presence of lymphocyte migration and liquid compounds T-cell-cell and the target antigen

Moreover, the failure of oral lichen planus T cells and secretion of chemokines in human cells and tissue kypselidoton degranulation of mast cells with TNF-alpha release stimulants, TNF-a increased secretion of chemokines, and thereby cause damage to infinity. Inhibits the binding of retinoic acid in PPA-based cell-mediated immune response, cell-activating factor, such as IL-2 and TNF-alpha levels, while retinoic acid-induced apoptotic cells in patients with oral lichen planus is pity the two combined effect of local OLP less damage chronic inflammation, improves the clinical symptoms.

Retinoic acid metabolism may contribute to the development and differentiation of epithelial cells. It is used in cosmetics and pharmaceuticals for cosmetic raw material suppliers. Retinoic acid receptors in the human body play an important role in epithelial cell differentiation, inflammation. The retinoic acid has side effects. Therefore, the initial dose is small. The medication should not begin unless half of year passed. It should remove the local stimulus before using it, and otherwise it will easily lead to cancer. Source:http://www.cosprm.com