In recent decades, there are an increasing number of diseases associated with obesity and diabetes. The non-alcoholic fatty liver disease has become increasingly a concern. NAFLD has become a risk factor for liver disease and hepatocellular carcinoma. So far, energy control has become the most effective method for the treatment of NAFLD. However, this method is difficult to be effective for most patients with NAFLD.

Studies have shown that resveratrol mimics the effects of CR to reduce the risk of diseases such as heart disease, diabetes, cancer, neurological disorders. In mice, it was found that resveratrol can protect the liver damage caused by a high fat diet may reduce the deposition of fat in the liver. It has been reported, but less in an in vitro model to study the effect of resveratrol fatty liver. The study of soft fat, sodium, and live human cells, HepG2 cells and fat deterioration caused by the effects of resveratrol, such as intracellular triglycerides.

To determine the effect of resveratrol on the accumulation of lipids in cell media, the cells were incubated for 24 hours, Quantification of oil red O staining of the different lipid components of the cell. Compared with the control group a significant increase in lipid concentration of high fat group. However, the lipid concentration of resveratrol in the group of fat at a level basis. These results suggest that resveratrol prevents the soft fat sodium, due to intracellular accumulation of lipids.

In recent years, as well as developed countries, developing countries, the increasing prevalence of obesity and diabetes and the second non-alcoholic fatty liver disease associated notes that almost two people. Epidemiological data suggest that NAFLD prevalence of obesity 74%, 90% moderate obesity. NAFLD has become the most common liver failure.

Unsaturated fatty acids (especially polyunsaturated fatty acids) in the hepatoprotective effect of unsaturated fatty acids, toxic effects on the liver, the latter in the pathogenesis of alcoholic fatty liver plays an important role. The normal human body or the body of patients with nonalcoholic fatty liver is the largest amount of saturated fatty acids palmitic acid. Therefore, the soft fat, sodium, and fat cells caused by the decrease in the best conditions simulating alcoholic fatty liver disease. Choose a research interest in HepG2 cells, hepatic steatosis fat and sodium induced soft that resveratrol can reduce the concentration of intracellular fat droplets.

The results show that the pharmaceutical raw materials olefin can significantly increases sodium concentration in intracellular lipid droplets. The concentration of sodium palmitate located near the border of intracellular lipid droplets. Therefore, resveratrol significantly prevents sodium mole to cause triglyceride fat. In conclusion, NAFLD is located near the in vitro model. It confirms that resveratrol has improved the situation in fatty liver, but the exact molecular mechanism is unclear. It needs further study. Source:http://www.cospcn.com