Glutathione is a peptide of three amino acids. It almost exists in every cell of the body. Glutathione can effectively work in the human body under the conditions of the cells and their precursors (vitamin C and alpha lipoic acid). Glutathione helps to maintain normal immune system’s function. There is an effective immune response occurred in the breeding lymphocytes (cell-mediated specific immunity). The immune system of cells produces many oxiradicals. Because their normal operation requires a higher concentration of antioxidants, glutathione played an important role.

Glutathione has a variety of important physiological functions in vivo, in particular plays a vital role in the maintenance of appropriate vivo redox environment. It participates in the detoxification of foreign body and electrophilic metabolites, is an effective free radical scavenger, protect cells from the damage of reactive oxygen compounds. As early as the 1920s and 1930s, began its study. Now, glutathione as a drug already widely used in people, treatment of many diseases, but also as a functional food and nutrition fortifier used in food processing industry. Japan and other developed countries in the 1950s began to glutathione and actively developed as a biologically active additives used in the production of health food. On glutathione late start, especially food, is the first start-up phase.

In aquaculture, adding the appropriate dose of glutathione and astaxanthin can improve the antioxidant capacity of tilapia muscle tissue and vannamei pancreas, grass carp and tilapia serum IGF - 1 levels, to promote this the growth of several aquatic animals. China is still not glutathione reports for use in ruminant animals. In addition, glutathione can improve the lactating animal's lactation glutathione to maintain the biological function of the male and female embryonic cells, improve the conception rate and promote the early development of the embryo. Thus, glutathione can improve the reproductive performance of animals.

In recent years, with the glutathione widely used in various fields, its production methods have been studied extensively. Manufacturing methods of glutathione are solvent extraction, chemical synthesis, fermentation and enzymatic. In early tome, glutathione production is mostly solvent extraction and chemical synthesis, is used mainly by microbial fermentation (especially yeast fermentation), using recombinant DNA technology to build high-yielding engineered bacteria is the main object of the present study and focus on chemical synthesis law and yeast fermentation industrialized production of glutathione, the enzymatic production of glutathione is in the laboratory research stage, yet to achieve industrialization. Currently, glutathione’s higher prices limit the research and application of glutathione and tretinoin in animal production. Glutathione becomes a cosmetic raw material, feed additives and therapeutic agents using in certain poultry diseases. In addition to carrying out extensive and in-depth study, it is also particularly important to reduce its production costs.Source: