Application of glutathione in the treatment of hepatic cirrhosis
June 8, 2012Recent studies have proved that pathological damage process of hepatic cirrhosis is is closely related to free radicals. Reducing the damage of free radicals on the body can relieve the pathological damage process of hepatic cirrhosis. In experimental application, the reduced glutathione injection is used in treatment of patients with hepatic cirrhosis. They also buy glutathione to observe its functions in removing free radicals. And its derivatives have membrane attack effect on liver cells. Thus reduced glutathione has influenced the antioxidant capacity in hepatic cirrhosis patients.
The endotoxemia is caused by free radicals when people get live disease. Number of free radicals on the one hand consume the body of antioxidants, such as: glutathione peroxidase, superoxide dismutase and glutathione content to reduce, resulting in the antioxidant functions to reduce the other hand, damage the body membrane structure, causing changes in function and antigen-specific, and then lead to the virus and antigen-antibody complex to remove obstacles, and damage to liver cells, the cycle, and ultimately the liver showed chronic damage to provide a pathological basis for the formation of liver fibrosis . Accelerate the application of the process of liver fibrosis in anti-drug free radicals can break the vicious cycle of free radical induced removal of the liver damage factors, slowing liver fibrosis.
Glutathione synthesis is an intracellular tripeptide composed by glutamic acid, cystine, and glycine, to participate in the reduction reaction of many peroxides. Such as hydrogen peroxide and lipid peroxides, the particle biotransformation process to produce the H202 into H20, to block or reduce the lipid peroxidation in a reaction, so that the transformation of the formation of lipid peroxides into non-toxic alcohol, blocking two trigger reaction occurred effectively eliminate the role of free radicals and their derivatives on liver cell membrane attack, and thus play an important role in the protection of the structure of biological macromolecules in cells.
After two weeks in research and application of reduced glutathione treatment, sclerosis in patients with red blood cell glutathione content was significantly increased red blood cell content of MDA decreased significantly. Inosine group in patients with red blood cell glutathione content increased erythrocyte malondialdehyde content decreased, but the small changes and glutathione group. Glutathione content of the two treatment groups there are still significant differences in MDA content did not result in differences may be related to the treatment is too short. To more effectively reduced glutathione as an antioxidant free radical scavenging, to correct the imbalance of free radicals and antioxidant systems, improve the status of the disease. The pharmaceutical raw materials have positive significance in treatment and prognosis of liver disease.
Reduced glutathione is a kind of white crystalline powder equipped with 3 or 4ml of solvent. It is applied in a variety of organophosphate poisoning, alcoholism, drug toxicity (anti-tumor, anti-tuberculosis, central nervous system drugs and paracetamol, etc.). It can prevent liver injury from radiation damage and various causes.
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