Anti protein non-enzymatic glycation and antioxidant activity of resveratrol
April 4, 2012Research on resveratrol’s anti-protein non-enzymatic glycosylation and antioxidant activity finds that it is dose-dependent. The effect of anti-protein non-enzymatic glycation is more effective than that of catechins, antioxidant effect is slightly worse. Resveratrol has potential applications in the pond base or chia seed oxidation which is closely related to the prevention and treatment of disease. It is worth further research and development.
Protein non-enzymatic glycosylation refers to the protein amino acid N terminal amino or side chain amino and reducing sugar aldehyde condensation, resulting in reversible Shiff's base intermediate thereby forms stable and reversible sugar protein complexes - amino -1 - deoxy-D ketose, the Amadori product. Amadori products or degradation of a variety of highly reactive carbonyl compounds, reaction with other free amino groups, through a series of chemical rearrangement and dehydration reactions, to generate the depth of irreversible glycosylation end products of AGEs. AGEs in the body long-term accumulation, can trigger a series of pathological changes, eventually leading to atherosclerosis, aging, chronic complications of diabetes and alzheimer's development of the disease. The occurrence of the disease to handle the inhibition of protein non-enzymatic glycation process, can prevent, delay, prevent AGEs formed. In recent years, many experts and scholars in this field have research and discussion. Some polyphenolic substances, especially flavonoids on the formation of AGEs has a strong inhibitory effect, and some commonly used traditional Chinese medicine, such as docetaxel, pueraria, water milk thistle, were screened and found that they are potential inhibitors of AGEs. Application of AGEs inhibitors in vitro model for screening flavonoids catechin as control, anti-protein non-enzymatic glycosylation of resveratrol activity were evaluated and found that resveratrol has a strong inhibition of AGEs is a good inhibitor of AGEs.
The occurrence and development of many diseases such as atherosclerosis, hypercholesterolemia, and oxidation are closely related to traditional Chinese medicine or effective parts of monomer compounds. Anti-oxidative capacity was measured by in vitro test model, can be quickly and efficiently find new antioxidants. Using in vitro models, as the control, catechin on resveratrol's antioxidant activity was evaluated and found that resveratrol has a strong antioxidant capacity.
Resveratrol and catechin has good anti-protein non-enzymatic glycosylation and basic in a dose-dependent manner. Concentrations up to 600μg/ml, almost completely inhibited the formation of AGEs. In comparison, the resveratrol show stronger inhibitory activity of l. The proteins depth glycation end products AGEs not only direct chemical cross-linking occurs through the promotion of protein to affect the structure and function of the organization, but also cause tissue damage through oxidative stress and its long-term accumulation in the body can trigger a series of pathological changes, eventually leading to the development of the disease of atherosclerosis, aging, chronic complications of diabetes and old age dementia. Stilbene compound resveratrol display inhibitory activity than the flavonoids catechin more of AGEs, suggesting the potential AGEs inhibitors with good activity, and even their respective stilbene compounds are likely to exhibit good activity worthy of further study.
Resveratrol is an anti-toxins produced in plant invasion of pests and ultraviolet radiation. It is widely distributed in nature and its derivatization is also easier to operate. In view of its good performance of the activity, resveratrol and its derivatization products have broad medicinal prospects. It is worthy of further development and utilization.
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Posted by tracy ma. Posted In : pharmaceutical raw materials