Biotin is a necessary water-soluble vitamin for growth of human and animals. In 1901, scientists isolated biotin from the yeast culture medium and proved that it can promote the growth of microorganisms. In past, people generally believed that biotin was widely present in the feed and can be synthesized by bacteria in animal gut, so it was sufficient to meet the needs of the animal growth. It was no necessary to add it in dietary. In production practice, they are many biotin deficiency situations, and it even leads to death in severe cases. Supplemental biotin can make the symptoms disappeared. Therefore, biotin is one of the key ingredients of animal feed. And it is becoming the most popular vitamin supplement.

Biotin is widely present in plants and animals, naturally occurring biotin combined with other molecules in the form of existence. Its chemical structure, including one containing five carbon atoms of carboxyl side chains and two five-membered heterocyclic rings. It plays a coenzyme role in the body by the side chain carboxylic acid and enzyme protein ε-lysine residues. Biotin has a total of eight different stereoisomers. According to the study from biotin supplier, only the D (+) biotin has biological activity.

Supplemental biotin for the role of fat metabolism of growing and finishing pigs to reduce backfat and improve carcass quality. It has been confirmed that biotin can eliminate the adverse effects of high levels of copper pig backfat. It has been reported that, feeding the lack of biotin in the diet will lead to saturated fatty acids are converted to unsaturated fatty acids result in lower body fat quality, added biotin can increase lean meat and improve meat and flesh.

Biotin can promote the development of immune organs, improve the immune organ weight index; with the increased levels of biotin added, the better the development of immune organs. The addition of biotin can significantly increase the expression levels of proliferating cell nuclear antigen gene. Spleen as a peripheral immune organ in the body's immune response play a very important role, so add biological factors may promote the increase PCNA levels of PCNA gene mRNA expression and to promote DNA replication to promote spleen cells in the proliferation and differentiation, to improve the spleen of metabolic conditions and promote the play of the spleen, thus improving the immune function. In addition, biotin can also promote the cellular immune response and humoral immune responses, increase in serum globulin levels and newcastle disease antibody titers and IgG levels. It significantly increased the conversion rate of T, B lymphocytes in the blood.

Animal biotin demand not only with the animal species and different by animal age, the impact of physiological state, feed ingredients, feed traits, genetic strain caused by the differences and breeding patterns. In addition, based on different assessment criteria are also different requirements.

Biotin is a vitamin which arouses great concern in recent years. As a coenzyme of carboxylase system, it plays an important role in the metabolism of carbohydrates, lipids and proteins. Biotin is widely used in human cosmetic and hair loss treatment by cosmetic raw material suppliers. Study of biotin on animals stays in the level of the requirement. Its physiological function, mode action, pathological mechanisms and metabolic pathways all lacks of a systematic and in-depth discussion. As people have gradual deepening understanding of biotin, it has become an indispensable additive in animal nutrition. Its functions will gradually be revealed.