Recent studies have shown that resveratrol found in plants and food (especially found in red wine) can extend the healthy life through increasing activity of mitochondria to provide energy for the cell. Without mitochondria to enhance the gene SIRT1, resveratrol does not work.

In the past decade, pharmaceutical raw materials suppliers describe how resveratrol promotes the intracellular energy production and overall health by activating a class of called sirtuin mitochondrial functional genes. Mitochondria as the cell's energy suppliers are crucial for the longevity and overall health. The scientists studied the sirtuin gene of several model organisms, including yeast, nematodes, fruit flies and mice. The first three organisms, they are completely knocked out of SIRT1 and found that the cells lack this gene does not resveratrol response. But they can not be observed in mice, these effects because of the absence of SIRT1 gene in mice born died.

In order to solve this problem scientists have designed a new mouse model. All aspects of look completely normal mice injected tamoxifen its SIRT1 gene will be completely closed. This is a drug-induced systemic gene inhibition. Gene suppression is rare. The further implication is that, this mouse model is also valuable for many different laboratories of other research areas. The results are very simple: after the failure of the mouse SIRT1 gene to mice a small amount of resveratrol, the researchers did not detect the enhancement of mitochondrial function. Conversely, when to mice with normal SIRT1, resveratrol detected mitochondrial energy has increased significantly.

Resveratrol’s attractive prospect in extending the healthy life causes a strong interest in science. Some pharmaceutical raw materials suppliers have questioned the contact of resveratrol and the SIRT1 gene. One theory is that resveratrol may activate a separate energy pathways of AMPK. AMPK pathway is also related to mitochondrial function, but it does not include the sirtuin gene. In mice without SIRT1, it will not react with resveratrol. The AMPK has not been affected. When the dose is significantly increased, the AMPK pathway is activated. But it not helpful for mitochondrial function.

Resveratrol is a dirty molecule. So if people know where to buy resveratrol and very large doses are used, many cases are likely to occur. The standard practice in the study of molecular interaction is that use the lowest dose to produce effects in order to avoid excessive use and affect the other sides. But SIRT1 genes will be necessary for downstream effectors to increase the energy. Studies have shown that regardless of any doses of resveratrol, SIRT1 gene is primary and important.

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