Study on irinotecan and polymorphisms of UGT1A1 gene
In the worldwide, morbidity and mortality of gastrointestinal tumor ranks first in the forefront of all malignant tumors. Its biological characteristics have a high invasive. After radical surgery, there are about 50% of patients who have recurrence or metastasis, even it is late when they find it. In the past decade, one of the important progresses of pharmaceutical raw materials suppliers’ clinical research is to establish the value of chemotherapy in advanced gastrointestinal cancer patients. Compared with best supportive care, chemotherapy helps prolong survival and improve quality of life.
Since the irinotecan come out in late 1990s, the treatment of advanced gastrointestinal tumors has new breakthroughs. The LV compared with BSC or 5-FU and irinotecan as first-line or second-line treatment failure of 5-FU treatment could significantly improve survival of advanced gastrointestinal tumors, showing good efficacy and survival advantage, but the application subject to the limitations of its possible serious toxicity, the irinotecan dose-limiting toxicity in healthy reduced delayed diarrhea and neutropenia.
Urgent need to
explore to be able to predict chemotherapy toxicity indicators used to guide
clinical and genetic polymorphisms of which drug metabolism is one of the main
factors causing adverse reactions difference between individuals. Irinotecan
Kang's main metabolizing enzyme UGT
The UGT
In patients with irinotecan
chemotherapy, TATA-box gene polymorphism (TA) 6 \ (TA) 7 heterozygous state in the
UGT