In traditional Chinese medicine in China, animal medicine is a unique and effective category. The application of animal medicine has a long history in China, recorded in ancient herbal medicine with a total of 600 kinds of animal medicine. According to the latest statistics, China now has about 1850 medicinal animal species. Although the role of animal drugs extensively, but in the species distribution on the functional indications, there is the relative concentration of the situation, mainly in Pingganxifeng, stasis, Endometriosis, kidney yang and so on. Recent studies have found that some animal drugs for the treatment of certain cardiovascular diseases.
Although the efficacy of animal drugs for all to see, but its complex internal structure of matter, the technical requirements needed for higher study, China's current basic research on these drugs is relatively weak. Relative to the herbal, animal separation and purification of drugs, active substances basic research, mechanism of efficacy, pharmacokinetics relative lack of research in the field. In addition, animals containing the mutant proteins are allergens, how to completely remove contaminating proteins and make the most effective protein to maintain the biological activity, which is essential for the safety of medicines, animal medicine is currently facing major challenges .
Currently animal medicine extraction, separation means more, which is extracted with water / alcohol extraction of the main. And plant medicine is different is that animal medicine has used to extract the enzyme and other biochemical means. Macroporous resin plant in traditional Chinese medicine commonly used separation means the separation of traditional Chinese medicine for the animal when more factors to consider, resveratrol because the animal protein component of Chinese medicine on the temperature, pH, etc. have higher requirements.
As China has successfully developed and production animal medicine injection products, one of the few, the Friends of stroke medicine production technology to explore the successful experience is worth learning. Its production Shuxuetong injection is China's first use of modern bio-pharmaceutical technology developed by animal compound Chinese medicine injection, by the leech, earthworm extract two taste animal medicine made with anticoagulation, fibrinolysis, platelet aggregation and other pharmacological effects.
Technological innovation is that it has successfully developed China's first injection of compound animal medicine anchor. In Shuxuetong of production, which uses repeated freezing and thawing process, only adding saline to maintain a class of small peptides and other active ingredients of biological activity, Irinotecan but also to avoid the introduction of organic solvent to ensure maximum safety of the product; use hot processing technology, part of oligomeric peptides into amino acids dissolved in the extract, the other aggregation, coagulation and precipitation precipitation, in order to remove. The use of molecular sieve filtration technology for isolation and purification, both prone to allergic reactions to remove the large molecular weight substances, to ensure the injection in 6000 contained the following molecular weight substances, to avoid allergic reactions, but also retains a physiological activity sugars, small peptides, amino acids and other ingredients to make the product safe and effective.
For pharmaceutical raw materials, animal control is also a need to strengthen traditional Chinese medicine injection place. Production chain from source to do quality control, and then consolidate the detection of intermediate links, product quality can be effectively controlled from start to finish. To control product quality from the source to the target, it has established in Shandong Micro Leech Lake base, designated the area designated for the leech farming, procurement areas and designated areas, Yulin, Guangxi fixed procurement area. Base for the establishment of quality control not only for raw materials provides a strong guarantee, but also pull the entire chain of economic development. Source:http://www.cospcn.com