When the epidermis of skin aging, the metabolic rate will slow down, and the cuticle often can not fall off in time, so that the surface of the skin will be rough. Use a gentle skin exfoliation agent can promote aging of cells in the stratum corneum of the bonding force between the reduced and accelerate cell renewal rate and promote cell death from the other to achieve the purpose of improving the skin condition, have to make the skin smooth, delicate, soft effect on the skin with wrinkles, anti-aging effect.
Commonly used in cosmetics ingredients have a skin exfoliation agent hydroxy acid (AHAs) and B-hydroxy acid (BHA), a-hydroxy acids include glycolic acid, lactic acid, citric acid, malic acid, benzene, glycolic acid and tartaric acid, present in the majority fruits (lemon, apple, grape, etc.), commonly known as acid. High concentrations of AHAs can be used for the chemical peel skin, and low concentrations of AHAs make the activity of epidermal thickening, biotin and can reduce the adhesion of epidermal keratinocytes and increased dermal mucopolysaccharide, hyaluronic acid content, the increase in collagen formation in the lower wrinkles and increase skin smoothness and toughness, thereby improving photoaging of the skin caused by aging performance.
B-hydroxy acids are mainly from the natural growth of plants such as willow bark, wintergreen leaves and birch bark extract out, is a new generation of acid-soluble, water-soluble than the traditional acid and a stronger affinity to the skin and penetration, a sustained-release effect, the mouth of the hair follicle keratosis soluble material, the pores shrink, the use of acid concentration only one-fifth of the traditional, minoxidil moderate and efficient. Cosmetics in the current reference to "plant extracts" is also often a certain role in skin exfoliation.
Cytokines can promote and accelerate cell growth, proliferation, synthesis of protein or peptide material, in the ease of skin aging and skin has an important role in wound repair. Current prevention and treatment of skin aging and beauty in the application of cytokines on the epithelial cells are strongly growth-promoting effects of epidermal growth factor (EGF), fibroblasts and vascular endothelial cell growth-promoting effect of fibroblast growth factor ( FGF), insulin-like growth factor (IGF), platelet-derived factor (PDGF) from the mesoderm and stimulate fibroblast proliferation and collagen and elastin synthesis, can also stimulate angiogenesis, tretinoin but also inhibited from ectoderm proliferation of keratinocytes selective cell activator of transforming growth factor p (TGF.p). However, most of the growth factor does not heat and the larger molecular weight is not easy to limit their use of percutaneous absorption.
Current from human placenta extract isolated from human placenta source to promote cell growth factor (HPGF.1) is a small molecular weight peptides, the high thermal stability, high fever after 90 ~ C after the growth of a variety of cells role in promoting proliferation, is expected to slow down skin aging are widely used.
And because the skin aging process, the membrane of the cell growth factor receptor gradually decreased, with the corresponding cell growth factor binding ability and sensitivity decreased. Growth factor receptor activator is also used to improve the corresponding cells in vitro and in vivo biological effects of growth factors to achieve the role of aging skin. Source:http://www.cosprm.com