Since May 1983, China began extensive use of retinoic acid for the prevention of esophageal cancer in high incidence regions of esophageal cancer. The good results make the world also began to study the prevention of retinoic acid to treat other cancers.


Retinoic acid treatment of cutaneous squamous cell carcinoma in addition to clinical efficacy in the prevention of cutaneous squamous cell carcinomas also happened to have some effect, but applied to the clinical treatment of human use of tretinoin treatment of squamous cell carcinoma, and do not need special effects. The first stage with nine clinical trials of cis-retinoic acid, which confirms the role of retinoic acid treatment of cancer of the lung, breast, colon, head and neck, skin cancer or ovarian cancer is not just a basket of 13 phase II trial of retinoic acid and alpha-interferon, and found that 68% of the responses to the treatment of squamous cell skin cancer, as adjuvant treatment for head and neck cancer specific impact.


In fact, the first use of retinoic acid to treat acne and oral leukoplakia with good results from most experiments and clinical trials designed with the features of squamous cell lesions. It was found that human oral cancer cells implanted in nude mice can be cis-retinoic acid to increase the effectiveness of nine treatments, clinical cisplatin, an integrated approach to tumors of the head and neck also caused the problem in addition to introduce experiments that were not arbitrary or reproducible clinical outcomes studies, and some even contradictory, the main reason for the difference is opposite to stimulate cell growth and differentiation mechanism of cell cycle to promote cell physiology may change due to the cells can not be summarized as cosmetics material retinoic acid treatment of specific cells, which may have different reactions.


Currently, the largest range of retinoic acid treatment produces side effects like dry mouth, abnormal liver function, although it is not a serious problem, but it will reduce the willingness of patients treated. Retinoic acid treatment effects, in fact, it is consistent with the different tissues of different retinoic acid receptor, ie the final strategies for tissue specific activity, but the synthesis of certain types of retinoic acid receptor-specific drugs, in line with this strategy, just some new products are the first stage and second stage of clinical trials, and soon we were on the market as an effective treatment of retinoic acid of acute promyelocytic leukemia similar products.