Although majority of the catch-up growth research has focused on the high risk of disease and insulin resistance, however, affect of catch-up growth on bone metabolism, especially for adult bone metabolism is still little in detail explore. The diet is a factor that can be controlled. After refeeding, the impact of different dietary patterns on bone topic is worthy of an in-depth study. It has been confirmed that resveratrol and glutathione have many positive effects on mammals in physiology, which also includes the promotion of bone growth.

The catch-up growth can cause insulin resistance, and common in the insulin resistance syndrome in low-level systemic inflammation. Tumor necrosis factor A is an important inflammatory cytokine. Tumor necrosis factor antagonist therapy may be the prevention of bone damage bone metabolism, and increase bone mineral density in both a positive impact.

Studies have shown that dietary restrictions have a significant negative impact on bone. Eight weeks of normal diet under the catch-up growth compared to the high fat diet, on bone mineral density better improvement, or even revert to normal chia seed levels. Studies have shown that the generated bone in the two years after refeeding in adolescents with anorexia nervosa patients return to normal levels, however, bone mineral density was still significantly lower than the experimental control group. Compared with anorexia nervosa, four weeks of diet for bone metabolism damage is relatively minor, so the bone mineral density returned to normal levels after refeeding.

Studies have shown that resveratrol dosing group, the bone is significantly better. In addition, the concentration of bone and serum tumor necrosis factor has a significant negative correlation, and the weight a significant positive correlation. In conclusion, catch-up growth part of the reply calorie intake limit the adverse effects on bone health, this phenomenon is particularly marked in the normal diet refeeding group. In addition, resveratrol in the catch-up growth period for bone preventive protective effect, however, this protective effect depends on adequate nutrition intake. The serum levels of tumor necrosis factor concentration and weight also play an important role in the regulation of bone. Resveratrol has anti-inflammatory effect, can increase bone formation while avoiding excessive weight gain. This finding can be used as a reference to the development of new drugs with the potential for the development of obesity and crisp bone therapy.

Refeeding of the normal diet, comparing with a high fat diet, it has better improvement in bone mineral density. Resveratrol has preventive protective effect for catch-up growth period of the bone health. The concentrations of serum tumor necrosis factor and body weight also play important roles in the regulation of bone. Results of this study has great significance for the treatment of obesity and crisp bone.Source:http://www.cospcn.com